Note:
1) The releases before December 7, 2009 contain genetic interactions mostly from BioGRID. We are sorry for inconveniences.
2) The download files of Feb 25, 2011 and after only contain protein-protein interactions, of which both partners are from the same species.

Release: December 10th, 2012

Organisms Binary interactions* Complexes**
Homo sapiens 108477   (download: MITAB format  SIF format) 4136
Saccharomyces cerevisiae 112663   (download: MITAB format  SIF format) 6190
Caenorhabditis elegans 11025   (download: MITAB format  SIF format) 45
Drosophila melanogaster 46830   (download: MITAB format  SIF format) 353
Mus musculus 8183    (download: MITAB format  SIF format) 500
Rattus norvegicus 2287    (download: MITAB format  SIF format) 124
Arabidopsis thaliana 10690    (download: MITAB format  SIF format) 262
Original databaes (version)
IntAct Oct. 4, 2012
BioGRID 3.1.93
MINT Dec 21, 2010
DIP June 14, 2010
HPRD April 13, 2010
MIPS/MPact Oct 1, 2008
* Number of interactions: The number is the sum of self-interaction and binary interaction that all participating proteins have UniProt Accession Number.
** Number of complexes: The number is the sum of complexes that all participating proteins have UniProt Accession Number.

Release: June 28th, 2011

Organisms Binary interactions* Complexes**
Homo sapiens 74288   (download: MITAB format  SIF format) 3382
Saccharomyces cerevisiae 90252   (download: MITAB format  SIF format) 6020
Caenorhabditis elegans 10323   (download: MITAB format  SIF format) 36
Drosophila melanogaster 39905   (download: MITAB format  SIF format) 284
Mus musculus 5512    (download: MITAB format  SIF format) 377
Rattus norvegicus 1422    (download: MITAB format  SIF format) 106
Original databaes (version)
MINT Dec 21, 2010
IntAct April 19, 2011
DIP June 14, 2010
BioGRID 3.1.76
HPRD April 13, 2010
MIPS/MPact Oct 1, 2008
* Number of interactions: The number is the sum of self-interaction and binary interaction that all participating proteins have UniProt Accession Number.
** Number of complexes: The number is the sum of complexes that all participating proteins have UniProt Accession Number.

Release: Feb 25th, 2011

Organisms Number of interactions*
Homo sapiens 77158
Saccharomyces cerevisiae 81698
Caenorhabditis elegans 10206
Drosophila melanogaster 41933
Mus musculus 3969
Rattus norvegicus 1570
Original databaes (version)
MINT July 28, 2010
IntAct Oct 7, 2010
DIP June 14, 2010
BioGRID 3.1.69
HPRD April 13, 2010
MIPS/MPact Oct 1, 2008
* Number of interactions: It is the sum of self-interaction, binary interaction and complex.


Release: March 4, 2010

Organisms Number of interactions*
Homo sapiens 68819
Saccharomyces cerevisiae 79421
Caenorhabditis elegans 10607
Drosophila melanogaster 44851
Mus musculus 6555
Rattus norvegicus 2493
Original databaes (version)
MINT Nov 9, 2009
IntAct Feb 20, 2010
DIP Dec 30, 2009
BioGRID 2.0.62
HPRD July 6, 2009
MIPS/MPact Oct 1, 2008
* Number of interactions: It is the sum of self-interaction, binary interaction and complex.

Release: December 7, 2009

Organisms Number of interactions*
Homo sapiens 68415
Saccharomyces cerevisiae 72817
Caenorhabditis elegans 10609
Drosophila melanogaster 44505
Mus musculus 6514
Rattus norvegicus 2485
Original databaes (version)
MINT Nov 9, 2009
IntAct Nov 27, 2009
DIP Jan 26, 2009
BioGRID 2.0.59
HPRD July 6, 2009
MIPS/MPact Oct 1, 2008
* Number of interactions: It is the sum of self-interaction, binary interaction and complex.

Release: Augst 27th, 2009

Organisms Number of interactions*
Homo sapiens 66908
Saccharomyces cerevisiae 120717
Caenorhabditis elegans 10619
Drosophila melanogaster 47016
Mus musculus 6296
Rattus norvegicus 2439
Original databaes (version)
MINT Apr 22, 2009
IntAct Apr 17, 2009
DIP Jan 26, 2009
BioGRID 2.0.52
HPRD July 6, 2009
MIPS/MPact Oct 1, 2008
* Number of interactions: It is the sum of self-interaction, binary interaction and complex.

Release: May 15th, 2009

Organisms Number of interactions*
Homo sapiens 64518
Saccharomyces cerevisiae 118885
Caenorhabditis elegans 10325
Drosophila melanogaster 47146
Mus musculus 5703
Rattus norvegicus 1896
Original databaes (version)
MINT Apr 22, 2009
IntAct Apr 17, 2009
DIP Jan 26, 2008
BioGRID 2.0.52
HPRD Sep 1, 2007
MIPS/MPact Oct 1, 2008
* Number of interactions: It is the sum of self-interaction, binary interaction and complex.

Release: Jan. 8th, 2009

Organisms (number of interactions)
Homo sapiens 63229
Saccharomyces cerevisiae 110565
Caenorhabditis elegans 10437
Drosophila melanogaster 46179
Mus musculus 5461
Rattus norvegicus 1769
Original databases (version)
MINT Oct 24, 2008
IntAct Dec 22, 2008
DIP Oct 14, 2008
BioGRID 2.0.48
HPRD Sep 1, 2007
MIPS/MPact Oct 1, 2008