Source AC: | Q15831 |
Gene name: | LKB1 |
Protein name: | Serine/threonine-protein kinase STK11 |
Protein length: | 433 |
Keywords: | 3D-structure; Acetylation; Alternative splicing; Apoptosis; ATP-binding; Autophagy; Cell cycle; Cytoplasm; Differentiation; Disease variant; DNA damage; Kinase; Lipoprotein; Magnesium; Manganese; Membrane; Metal-binding; Methylation; Mitochondrion; Nucleotide-binding; Nucleus; Palmitate; Phosphoprotein; Prenylation; Reference proteome; Serine/threonine-protein kinase; Spermatogenesis; Transferase; Tumor suppressor; |
GO: |
GO:0005737 [cytoplasm] ECO:0000314 GO:0005829 [cytosol] ECO:0000314 GO:0070062 [extracellular exosome] ECO:0007005 GO:0140535 [intracellular protein-containing complex] ECO:0000314 GO:0016020 [membrane] ECO:0000250 GO:0005739 [mitochondrion] ECO:0000314 GO:0005654 [nucleoplasm] ECO:0000314 GO:0005634 [nucleus] ECO:0000314 GO:1902554 [serine/threonine protein kinase complex] ECO:0000353 GO:0030018 [Z disc] ECO:0007669 GO:0005524 [ATP binding] ECO:0000314 GO:0030275 [LRR domain binding] ECO:0007669 GO:0000287 [magnesium ion binding] ECO:0000314 GO:0002039 [p53 binding] ECO:0000314 GO:0030295 [protein kinase activator activity] ECO:0000314 GO:0106310 [protein serine kinase activity] ECO:0007669 GO:0004674 [protein serine/threonine kinase activity] ECO:0000314 GO:0044877 [protein-containing complex binding] ECO:0007669 GO:0032147 [activation of protein kinase activity] ECO:0000314 GO:0043276 [anoikis] ECO:0000315 GO:0006914 [autophagy] ECO:0007669 GO:0007409 [axonogenesis] ECO:0007669 GO:0071493 [cellular response to UV-B] ECO:0000314 GO:0097484 [dendrite extension] ECO:0007669 GO:0006974 [DNA damage response] ECO:0000315 GO:0060767 [epithelial cell proliferation involved in prostate gland development] ECO:0007669 GO:0030010 [establishment of cell polarity] ECO:0000315 GO:0070314 [G1 to G0 transition] ECO:0000314 GO:0042593 [glucose homeostasis] ECO:0000250 GO:0051645 [Golgi localization] ECO:0007669 GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] ECO:0000314 GO:0090090 [negative regulation of canonical Wnt signaling pathway] ECO:0000315 GO:0030308 [negative regulation of cell growth] ECO:0000250 GO:0008285 [negative regulation of cell population proliferation] ECO:0000315 GO:0120163 [negative regulation of cold-induced thermogenesis] ECO:0000250 GO:0060770 [negative regulation of epithelial cell proliferation involved in prostate gland development] ECO:0007669 GO:1904262 [negative regulation of TORC1 signaling] ECO:0000315 GO:0018107 [peptidyl-threonine phosphorylation] ECO:0000314 GO:0010508 [positive regulation of autophagy] ECO:0000315 GO:0050772 [positive regulation of axonogenesis] ECO:0007669 GO:0045722 [positive regulation of gluconeogenesis] ECO:0007669 GO:1900182 [positive regulation of protein localization to nucleus] ECO:0007669 GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] ECO:0000315 GO:1901610 [positive regulation of vesicle transport along microtubule] ECO:0000315 GO:0045059 [positive thymic T cell selection] ECO:0007669 GO:0046777 [protein autophosphorylation] ECO:0000314 GO:0006470 [protein dephosphorylation] ECO:0000315 GO:0034504 [protein localization to nucleus] ECO:0007669 GO:0006468 [protein phosphorylation] ECO:0000314 GO:0051726 [regulation of cell cycle] ECO:0000304 GO:0001558 [regulation of cell growth] ECO:0000250 GO:0048814 [regulation of dendrite morphogenesis] ECO:0007669 GO:0051896 [regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction] ECO:0007669 GO:1901796 [regulation of signal transduction by p53 class mediator] ECO:0000304 GO:0030111 [regulation of Wnt signaling pathway] ECO:0000318 GO:0014823 [response to activity] ECO:0007669 GO:0033762 [response to glucagon] ECO:0007669 GO:0010212 [response to ionizing radiation] ECO:0000250 GO:0033993 [response to lipid] ECO:0007669 GO:0097066 [response to thyroid hormone] ECO:0007669 GO:0007165 [signal transduction] ECO:0000318 GO:0007283 [spermatogenesis] ECO:0007669 GO:0050852 [T cell receptor signaling pathway] ECO:0007669 GO:0001894 [tissue homeostasis] ECO:0007669 GO:0001944 [vasculature development] ECO:0000250 |
InterPro: |
IPR011009 [Kinase-like_dom_sf] IPR039154 [LKB1_c] IPR000719 [Prot_kinase_dom] IPR017441 [Protein_kinase_ATP_BS] IPR008271 [Ser/Thr_kinase_AS] |
Organism: | Homo sapiens |
|
Source AC: | Q8TDC3 |
Gene name: | BRSK1 |
Protein name: | Serine/threonine-protein kinase BRSK1 |
Protein length: | 778 |
Keywords: | Alternative splicing; ATP-binding; Cell cycle; Cell projection; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; DNA damage; Kinase; Magnesium; Metal-binding; Methylation; Neurogenesis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Synapse; Transferase; |
GO: |
GO:0030054 [cell junction] ECO:0000314 GO:0005813 [centrosome] ECO:0000250 GO:0005737 [cytoplasm] ECO:0000314 GO:0150034 [distal axon] ECO:0000250 GO:0005654 [nucleoplasm] ECO:0000314 GO:0005634 [nucleus] ECO:0000314 GO:0048786 [presynaptic active zone] ECO:0000304 GO:0008021 [synaptic vesicle] ECO:0000250 GO:0005524 [ATP binding] ECO:0000305 GO:0043015 [gamma-tubulin binding] ECO:0000250 GO:0000287 [magnesium ion binding] ECO:0000314 GO:0019901 [protein kinase binding] ECO:0007669 GO:0106310 [protein serine kinase activity] ECO:0007669 GO:0004674 [protein serine/threonine kinase activity] ECO:0000314 GO:0048156 [tau protein binding] ECO:0000303 GO:0050321 [tau-protein kinase activity] ECO:0000314 GO:0008306 [associative learning] ECO:0000250 GO:0007409 [axonogenesis] ECO:0000250 GO:0051298 [centrosome duplication] ECO:0000250 GO:0006974 [DNA damage response] ECO:0000314 GO:0030010 [establishment of cell polarity] ECO:0000250 GO:0000086 [G2/M transition of mitotic cell cycle] ECO:0000314 GO:0035556 [intracellular signal transduction] ECO:0000318 GO:0090176 [microtubule cytoskeleton organization involved in establishment of planar polarity] ECO:0000250 GO:0007095 [mitotic G2 DNA damage checkpoint signaling] ECO:0000314 GO:0030182 [neuron differentiation] ECO:0000250 GO:0007269 [neurotransmitter secretion] ECO:0000250 GO:0018105 [peptidyl-serine phosphorylation] ECO:0000314 GO:0006468 [protein phosphorylation] ECO:0000314 GO:0050770 [regulation of axonogenesis] ECO:0000250 GO:0010975 [regulation of neuron projection development] ECO:0000250 GO:0048167 [regulation of synaptic plasticity] ECO:0000250 GO:2000807 [regulation of synaptic vesicle clustering] ECO:0000304 GO:0009411 [response to UV] ECO:0000314 GO:0099504 [synaptic vesicle cycle] ECO:0000250 |
InterPro: |
IPR048622 [BRSK1_2-like_UBA] IPR011009 [Kinase-like_dom_sf] IPR000719 [Prot_kinase_dom] IPR017441 [Protein_kinase_ATP_BS] IPR008271 [Ser/Thr_kinase_AS] IPR015940 [UBA] |
Organism: | Homo sapiens |
|
Comment 1 from: makelab members | |
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Believe this interaction: | Yes |
Comment: | PMID: 14976552 |