We are excited to be a part of a Lancet Oncology Commission focusing on cancer genomics and precision oncology. This new commission will be coordinated by the International Cancer Genome Consortium Accelerating Research in Genomic Oncology (ICGC-ARGO) initiative, and bring together international experts with relevant expertise across a range of fields, to offer practical solutions for key challenges in ensuring sustainable and equitable access to omics testing and a blueprint for advancing cancer diagnosis and treatment.