Pancreatic neuroendocrine tumors (PanNETs) are among the most common neuroendocrine tumors, and non-functional PanNETs (NF-PanNETs) represent about 90% of PanNETs, with highly variable behaviour from nearly benign to extremely aggressive.
In collaboration with a group of impressive leaders in cancer proteomics and pancreatic cancer, we performed a comprehensive proteogenomic analysis of treatment-naive NF-PanNETs. Together with functional investigation using conditional knockout mouse models and patient-derived organoids/xenografts, we gained insights into how frequent genomic alterations drive phenotypic changes in NF-PanNETs and unravelled proteomic subtypes with distinct clinical, molecular, and immune microenvironment features with specific therapeutic implications.
More details are online first now in Cancer Cell.
