J. Wu

Latest

• Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups
• Pharmacogenomic profiling of intra-tumor heterogeneity using a large organoid biobank of liver cancer
• ReProMSig: an integrative platform for development and application of reproducible multivariable models for cancer prognosis supporting guideline-based transparent reporting
• Accelerating cancer omics and precision oncology in health care and research: a Lancet Oncology Commission
• Deep-learning based approach to identify substrates of human E3 ubiquitin ligases and deubiquitinases
• Pan-cancer surveys indicate cell cycle-related roles of primate-specific genes in tumors and embryonic cerebrum
• Urine proteomic signatures predicting the progression from premalignancy to malignant gastric cancer
• Dual roles of β-arrestin 1 in mediating cell metabolism and proliferation in gastric cancer
• Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells
• In-Depth Comparison of Matrigel Dissolving Methods on Proteomic Profiling of Organoids
• DNA transposons mediate duplications via transposition-independent and -dependent mechanisms in metazoans
• PINA 3.0: mining cancer interactome
• CVCDAP: an integrated platform for molecular and clinical analysis of cancer virtual cohorts
• Multi-omics characterization of molecular features of gastric cancer correlated with response to neoadjuvant chemotherapy
• Precision Oncology in Surgery: Patient Selection for Operable Pancreatic Cancer
• Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
• Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins
• Impact of the Anticancer Drug NT157 on Tyrosine Kinase Signaling Networks
• Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy
• ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-beta signalling
• Clonality analysis of synchronous gastro-oesophageal junction carcinoma and distal gastric cancer by whole-exome sequencing
• Hypermutation In Pancreatic Cancer
• Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency
• Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes
• Signalome-wide assessment of host cell response to hepatitis C virus
• Whole-genome landscape of pancreatic neuroendocrine tumours
• Damage-inducible intragenic demethylation of the human TP53 tumor suppressor gene is associated with transcription from an alternative intronic promoter
• Genomic analyses identify molecular subtypes of pancreatic cancer
• Genomic analysis of HPV-positive versus HPV-negative oesophageal adenocarcinoma identifies a differential mutational landscape
• Resolution of Novel Pancreatic Ductal Adenocarcinoma Subtypes by Global Phosphotyrosine Profiling
• Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions
• The kinome 'at large' in cancer
• Nuclear factor kappaB-inducing kinase activation as a mechanism of pancreatic beta cell failure in obesity
• Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia
• SOX9 regulates ERBB signalling in pancreatic cancer development
• Whole genomes redefine the mutational landscape of pancreatic cancer
• Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling
• Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor beta Signaling
• Phosphoproteomic profiling identifies focal adhesion kinase as a mediator of docetaxel resistance in castrate-resistant prostate cancer
• Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways
• Targeting mTOR dependency in pancreatic cancer
• Ubiquitin-conjugating enzyme E2C: A potential cancer biomarker
• Characterization of the Novel Broad-Spectrum Kinase Inhibitor CTx-0294885 As an Affinity Reagent for Mass Spectrometry-Based Kinome Profiling
• Clinical and molecular characterization of HER2 amplified-pancreatic cancer
• Global characterization of signalling networks associated with tamoxifen resistance in breast cancer
• Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater
• Neuropilin-2 Promotes Extravasation and Metastasis by Interacting with Endothelial alpha5 Integrin
• Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells
• Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer
• Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
• PINA v2.0: mining interactome modules
• qpure: A Tool to Estimate Tumor Cellularity from Genome-Wide Single-Nucleotide Polymorphism Profiles
• RON is not a prognostic marker for resectable pancreatic cancer
• KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases
• Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme
• Integrated network analysis platform for protein-protein interactions
• Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites
• WebLab: a data-centric, knowledge-sharing bioinformatic platform
• KOBAS server: a web-based platform for automated annotation and pathway identification