Our recent work demonstrate that Staphylococcus is selectively enriched in metastatic lung tumor lesions. Staphylococcus nepalensis and S. capitis secrete lactate to promote the metastatic potential of tumor cells by triggering MCT1-mediated pseudohypoxia signaling. MCT1 inhibition abolishes metastasis in a murine xenograft model, highlighting potential avenues for targeting tumor-resident bacteria. Please check the article published in Cell Host & Microbe for more details. Congratulations to Huan Yu and Yang Du !
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma
